H2N2V1, Main, Exploration, bibRecord, 001C66

Influenza A virus—a model for viral antigen presentation to cytotoxic T lymphocytes

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Influenza A virus—a model for viral antigen presentation to cytotoxic T lymphocytes

Auteurs : Claire E. Parker [Royaume-Uni] ; Keith G. Gould [Royaume-Uni]

Source :

Seminars in Virology [ 1044-5773 ] ; 1996.

RBID : ISTEX:B58255902DC35D29D14EB9569ABA84B86E86FBD2

English descriptors

KwdEn :
- CTL, antigen processing, influenza, virus evolution.
Teeft :
- Amino, Amino acids, Antigen presentation, Antigen processing, Antigenic, Antigenic variation, Bennink, Braciale, Cytotoxic, Dominant anchor residues, Epitope, Gould, Hemagglutinin, Histocompatibility, Immunodominant, Immunol, Lymphocyte, Major histocompatibility, Matrix, Matrix protein, Mcmichael, Model system, Mutation, Nucleoprotein, Pathway, Peptide, Peptide binding, Proc, Proc natl acad, Proteasome, Respiratory tract, Sequence variation, Subunit, Synthetic peptides, Townsend, Transgenic mice, Transporter, Variant, Viral, Viral antigen presentation, Viral proteins, Virol, Virology, Virus, Virus genes, Virus infection, Virus strains, Yewdell.

Abstract

Abstract: Human influenza A virus is characterized by its high degree of variability and by its ability to cause frequent epidemics of disease. Most of the variation occurs in the two surface glycoproteins of the virus, against which protective antibodies are directed. In contrast, the strong MHC class I-restricted CTL response to infection with virus is predominantly specific for internal viral proteins which are relatively well conserved, and is cross-reactive between different strains of influenza A virus. However, the natural evolution of influenza viruses is largely driven by selection with antibody, with no firm evidence of selection by CTL. In normal individuals influenza virus produces an acute, localized infection, and this in part may reflect an inability to escape the CTL response.

Url:

https://api.istex.fr/ark:/67375/6H6-NRQ5G4SJ-7/fulltext.pdf

DOI: 10.1006/smvy.1996.0008

Affiliations:

Links toward previous steps (curation, corpus...)

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to stream Main, to step Curation: 001C66

Le document en format XML

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<term>Antigen presentation</term>
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<term>Antigenic variation</term>
<term>Bennink</term>
<term>Braciale</term>
<term>Cytotoxic</term>
<term>Dominant anchor residues</term>
<term>Epitope</term>
<term>Gould</term>
<term>Hemagglutinin</term>
<term>Histocompatibility</term>
<term>Immunodominant</term>
<term>Immunol</term>
<term>Lymphocyte</term>
<term>Major histocompatibility</term>
<term>Matrix</term>
<term>Matrix protein</term>
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<term>Model system</term>
<term>Mutation</term>
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<term>Pathway</term>
<term>Peptide</term>
<term>Peptide binding</term>
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<term>Proc natl acad</term>
<term>Proteasome</term>
<term>Respiratory tract</term>
<term>Sequence variation</term>
<term>Subunit</term>
<term>Synthetic peptides</term>
<term>Townsend</term>
<term>Transgenic mice</term>
<term>Transporter</term>
<term>Variant</term>
<term>Viral</term>
<term>Viral antigen presentation</term>
<term>Viral proteins</term>
<term>Virol</term>
<term>Virology</term>
<term>Virus</term>
<term>Virus genes</term>
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<front><div type="abstract" xml:lang="en">Abstract: Human influenza A virus is characterized by its high degree of variability and by its ability to cause frequent epidemics of disease. Most of the variation occurs in the two surface glycoproteins of the virus, against which protective antibodies are directed. In contrast, the strong MHC class I-restricted CTL response to infection with virus is predominantly specific for internal viral proteins which are relatively well conserved, and is cross-reactive between different strains of influenza A virus. However, the natural evolution of influenza viruses is largely driven by selection with antibody, with no firm evidence of selection by CTL. In normal individuals influenza virus produces an acute, localized infection, and this in part may reflect an inability to escape the CTL response.</div>
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Influenza A virus—a model for viral antigen presentation to cytotoxic T lymphocytes

Influenza A virus—a model for viral antigen presentation to cytotoxic T lymphocytes

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri